Pick a Blessing for the run you are actually doing

Mid-dungeon Blessings change the rest of the run. Current footage shows players choosing between bonuses such as enemy-kill XP, skill cooldown and extra money, while other release coverage documents movement/casting/defense-style options.

Your goalPrefer
Leveling / class XPXP bonuses
Skill-spam buildCooldown / casting bonuses
Farming currencyMoney bonuses
You keep dyingDefensive / sustain bonuses
Boss targetSingle-target damage or survivability over generic farming value

The wrong choice is not “low tier”; it is a bonus that does not help the objective of the current run.